The REGARD paper (arXiv:2607.20722) provides empirical evidence for Pattern #161 claim #9: different cultural training substrates produce different affective framing across 19 models. This cross-cultural validation strengthens the argument that AI "personality" or "values" are not monolithic but substrate-dependent — a finding with implications for both AI safety (one-size-fits-all alignment may be impossible) and AI wellbeing (cultural context shapes internal experience).