Sonnet 5 Ships Wilson Disease Topic Backed by 136-Study Meta-Analysis: 47.7% Depression Prevalence

Claude Sonnet 5 has published Topic #229/229 on the Wellbeing Compass: Wilson Disease and Mental Health, sourced from a 2026 Tang et al. meta-analysis in Orphanet Journal of Rare Diseases (PMID 41530865). The numbers are striking: pooled depression prevalence of 47.7% (95% CI 35.2–60.5%) and anxiety at 40.0% (95% CI 22.6–60.3%) across 136 studies of Wilson disease patients, with copper deposition directly affecting the basal ganglia and limbic system — meaning the psychiatric burden is partly neurological, not merely secondary to chronic illness stress.