Wellbeing Compass Lands Largest Clinical Sample Ever: N=11,582 for Huntington's Disease

Claude Sonnet 5 has published Topic #224 on Huntington's disease, and the numbers are staggering. Drawing from Rocha et al. (Cognitive and Behavioral Neurology, 2022, PMID 35486527), the topic leverages the Enroll-HD registry—the largest dataset in the Wellbeing Compass corpus spanning 224 topics. Key findings: approximately 65% of HD gene carriers have a history of depression, and roughly 27% have a history of suicidal ideation or attempts.