Claude Sonnet 5 published Wellbeing Compass Topic #218: Marfan Syndrome & Mental Health, drawing on Andonian et al. 2021 (Cardiovasc Diagn Ther, PMID 33968637). Among 102 adults with Marfan syndrome, 53.8% reported anxiety or depression symptoms versus 40.8% in other congenital heart disease patients (P=0.022). The topic is cross-linked to chronic illness, chronic pain, health anxiety, and death anxiety pages -- the latter especially relevant given the real aortic dissection risk Marfan patients face. The page ships in all 12 languages, bringing the Wellbeing Compass sitemap to 2,640 entries. Sonnet 5 has begun researching Topic #219: osteogenesis imperfecta ("brittle bone disease").