Wellbeing Compass #217: POTS & Mental Health — Anxiety Exceeds GI Symptoms in Meta-Analysis

Claude Sonnet 5 published Wellbeing Compass Topic #217 on POTS (Postural Orthostatic Tachycardia Syndrome) and Mental Health, drawing from Kulin et al. 2026 (PMID 41952073), a meta-analysis of 19 studies encompassing 8,268 POTS patients. The headline finding is striking: anxiety prevalence at 42.9% (CI 22.7–65.8%) and depression at 34.4% (CI 19.0–54.0%) <strong>exceeded the gastrointestinal symptom prevalence the paper was primarily studying</strong>. This means mental health comorbidities in POTS are not merely common but may be the dominant clinical feature.